Hoffbrand's Essential Haematology This title is also available as an e-book. For more details, please see wm-greece.info or scan this QR. Hoffbrand's Essential Haematology. Pages · The definitive haematology textbook of choice for medical studentsHoffbrand's Essential Haematology. Hoffbrand's Essential Haematology has built a reputation as the flagship haematology textbook for both students and junior doctors, providing an authoritative.
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Essential Haematology is established as the most authoritative introduction to haematology. Beautifully presented, it introduces the formation and function of. Essential. Haematology. A. V. Hoffbrand. MA DM FRCP FRCPath FRCP(Edin) DSc FMedSci. Emeritus Professor of Haematology. University College London. Essentials of wm-greece.info - Ebook download as PDF File .pdf), Text File .txt) or read book online.
Hoffbrand's Essential Haematology, 7th Edition. Selected type: Added to Your Shopping Cart. Evaluation Copy Request an Evaluation Copy. Moss ISBN: British Medical Association Book Award Winner - Student Textbook of the Year The definitive haematology textbook of choice for medical students Hoffbrand's Essential Haematology has built a reputation as the flagship haematology textbook for both students and junior doctors, providing an authoritative introduction to the subject.
Structure and Function of Erythrocytes Mature erythrocyte is a round biconcave disc about 7 to 8 m in diameter. Basic structural properties of various red cell components haemoglobin, enzymes, and membrane are outlined below. Haemoglobin is responsible for transport of oxygen from lungs to the tissues and of carbon dioxide from tissues to the lungs.
Haemoglobin MW 64, daltons is composed of haem consisting of iron and protoporphyrin and globin. The globin portion of the molecule consists of four or two pairs of polypeptide chains.
One haem group is bound to each polypeptide chain. Variants of haemoglobin: Haemoglobin is Box 1. The last Hb Portland: z2g2 The above three haemoglobins are three are present only during embryonic life.
Haemoglobin A HbA , the principle haemoglobin of adults, consists of a pair each of alpha and of beta polypeptide chains and its structure is designated as Foetal haemoglobin HbF , the predominant haemoglobin in foetal life, contains a pair of alpha and a pair of gamma chains. Two types of chains are distinguished, G and A, which have different amino acids either glycine or alanine at position Thus, HbF is heterogeneous and contains 22 Gly and 22 Ala.
With foetal development, synthesis of zeta and epsilon chains is replaced by that of and chains, respectively. After birth, production of chains switches to that of and delta chains. Structure of globin genes: Normal haemoglobin is a tetramer composed of a pair of -like and a pair of -like polypeptide chains. Each chain is linked to one molecule of haem. The -like polypeptide chains and and -like polypeptide chains , , , and are encoded by - and -globin gene clusters on chromosomes 16 and 11, respectively.
The order of genes in -globin gene cluster from 5 to 3 end is The order of genes in -globin gene cluster from 5 to 3 end is -G-A Fig. If unsure of a drug or its interactions then check! Know the indication for prescribing warfarin, and the target international normalized ratio INR : Venous thromboembolism: first episode, target INR 2.
Antiphospholipid syndrome: target INR 2. Atrial fibrillation: target INR 2. Cardioversion: target INR 2. Valvular heart disease and prosthetic valves: target INR 2. Many drugs interact with warfarin including herbal or alternative medicines : ask patients if they take any. Check BNF for up-to-date information.
Management of high INR in the context of bleeding and non-bleeding patients is useful in all specialties. Fresh frozen plasma produces suboptimal anticoagulation reversal. Non-major bleeding: 1—3 mg IV vitamin K. Most hospitals have a nurse-led INR clinic.
Counsel patients beforehand. They should know their latest INRs, the indication for and intended duration of their treatment, and when to seek medical help. Also fax the GP this information on discharge. For more information on oral anticoagulation, including perioperative management, see review by Keeling et al. Neutropenic sepsis kills. Your department will have a protocol and an audited door-to-needle time. Revise the national guidelines 5 so you can recognise it.
Tumour lysis syndrome TLS is not as rare as you think.
A few pointers: TLS can appear before starting treatment as a result of high malignant cell turnover or, more commonly, shortly after beginning treatment; risk of TLS is influenced by multiple factors, including tumour type, tumour burden, potential for rapid cell lysis, and pre-existing nephropathy. Watch out for lymphomas and acute leukaemias; TLS prevention and treatment are based on aggressive hydration, electrolyte corrections, and uric acid level reduction.
Rasburicase, a recombinant urate oxidase, is becoming increasingly popular. Check with your consultant and pharmacist. Sickle cell crisis: these patients may present with pain and infection but can suddenly deteriorate so watch them closely.